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omics-target-evidence-mapper

Aggregate public target-level evidence across omics and translational sources for research triage.

Published by ClawBio ↗ClawBio/ClawBio

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omics-target-evidence-mapper

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Use omics-target-evidence-mapper to compile public target-level evidence for [gene or protein target] in [disease context], producing JSON and Markdown research-triage reports with literature and relevant trial evidence; do not make causal, therapeutic-value, or clinical recommendations.

Required inputs

  • [gene or protein target]
  • [disease context]

User-approved starter prompt based on a pinned source version; check current skill requirements before running. Task evidence ↗

SKILL.md

name: omics-target-evidence-mapperdescription: Aggregate public target-level evidence across omics and translational sources for research triage.license: MITmetadata:   version: 0.1.0  tags:   - omics  - targets  - translational-research  - literature  - trials  openclaw:     requires:       bins:       - python3    always: false    emoji: 🧬    homepage: https://github.com/ClawBio/ClawBio    os:     - darwin    - linux    trigger_keywords:     - target evidence    - gene disease evidence    - target triage    - omics evidence    - gene disease mapper

Why This Exists

Researchers often need a quick first-pass view of whether a gene or protein target has evidence across multiple public sources. In practice, this usually means checking several websites manually and informally combining results. This skill makes that process reproducible by retrieving and organising public evidence into one structured output.

This skill is for research triage only. It does not infer causality, rank therapeutic value, or make clinical recommendations.

Core Capabilities

  1. Accept a gene or protein target and an optional disease term.
  2. Retrieve canonical target information from UniProt.
  3. Retrieve disease-target association evidence from Open Targets.
  4. Retrieve recent literature hits from PubMed.
  5. Optionally retrieve trial records relevant to the target and disease.
  6. Produce a machine-readable JSON file and a human-readable Markdown report.

Input Formats

ArgumentRequiredExampleNotes
--geneYes, unless --demo is usedIL6RGene or target symbol
--diseaseNocoronary artery diseaseOptional disease context
--outputYesdemo_outOutput directory
--max-papersNo5Number of PubMed hits to include
--max-trialsNo5Number of trial records to include
--demoNo--demoRuns the built-in demo query

Workflow

  1. Validate CLI inputs.
  2. Resolve the query from either user input or demo mode.
  3. Query public data sources.
  4. Normalise results into a structured evidence object.
  5. Write JSON and Markdown outputs.
  6. Write reproducibility bundle:
    • reproducibility/checksums.sha256 — SHA-256 hashes of all output files
    • reproducibility/environment.yml — pinned Conda/pip environment
    • ro-crate-metadata.json — RO-Crate 1.1 provenance record (run params, outputs, script)

CLI Reference

Demo mode

python skills/omics-target-evidence-mapper/omics_target_evidence_mapper.py --demo --output demo_out